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OddsShift · Oct 3, 2026

Brewers and Padres Set Lineups for NLDS Showdown

The Brewers and Padres have officially submitted their playoff rosters as they prepare to open the National League Division Series tonight in Milwaukee. Both clubs locked in their 26-man configurations, though San Diego made at least one adjustment to its initial announcement, swapping right-handed pitcher Randy Vasquez into the mix as a replacement for fellow starter Walker Buehler. The exact reason for Buehler's replacement remains unclear, adding an element of uncertainty to the Padres' pitching plans heading into Game 1.

Milwaukee will turn to Jacob Misiorowski on the mound in the series opener, tasking the right-hander with the high-pressure assignment of setting the tone at home. The Padres counter with veteran Robbie Ray, who brings playoff experience and a track record of big-game performances. Both teams have had weeks to prepare their rosters, but the late swap for San Diego suggests last-minute adjustments to health or matchup considerations that could still affect the series trajectory.

The roster decisions made now will shape how each team approaches a best-of-five series. Manager choices on bullpen depth, bench composition, and position player flexibility often determine how far clubs advance. With both clubs having selected their squads, the focus shifts entirely to execution on the field.

From a betting perspective, any uncertainty around the Padres' pitching depth—particularly with Buehler sidelined—could influence series odds and Game 1 pricing. If injuries or roster moves suggest San Diego's rotation is compromised, that might shift some value toward Milwaukee to advance, though much depends on how effectively Misiorowski pitches and whether the move ultimately proves inconsequential.

Source: original report ↗

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